Serpins in Health and Disease

The Bouton Group

Welcome to our lab,

Our projects are focused on studying the role of serpins, most particularly that of protease nexin-1 (PN-1).

Increased protease activities within the vascular wall is involved in the development of cardiovascular diseases. We have previously demonstrated that protease nexin-1, a major tissue antiprotease constitutes a key factor in the responses of vessels to injury, via its antithrombotic and antifibrinolytic properties.

In recent years, we have demonstrated that:

  • PN-1 is a serine protease inhibitor with an important protective role in tissues
  • PN-1 is a potent regulator of angiogenesis
  • PN-1 contributes to the regulation of lung fibrosis
  • Pharmacological targeting of PN-1 can help to improve haemophilia management and treatment

We now aim to determine its potential role in vascular pathophysiology and to:

  • develop innovative therapeutic strategies for the treatment of haemophilia.
  • understand the role of PN-1 in pathologies associated with a deregulated angiogenesis, such as diabetic nephropathy or peripheral artery disease.
  • inestigate how it can regulate inflammatory responses.

In collaboration with the Team 6 neuroplasticity group, we also aim at investigating the role of PN-1 in post-stroke cerebral remodeling.

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