Serpins in Health and Disease
The Bouton Group
Welcome to our lab,
Our projects are focused on studying the role of serpins, most particularly that of protease nexin-1 (PN-1).
Increased protease activities within the vascular wall is involved in the development of cardiovascular diseases. We have previously demonstrated that protease nexin-1, a major tissue antiprotease constitutes a key factor in the responses of vessels to injury, via its antithrombotic and antifibrinolytic properties.
In recent years, we have demonstrated that:
- PN-1 is a serine protease inhibitor with an important protective role in tissues
- PN-1 is a potent regulator of angiogenesis
- PN-1 contributes to the regulation of lung fibrosis
- Pharmacological targeting of PN-1 can help to improve haemophilia management and treatment
We now aim to determine its potential role in vascular pathophysiology and to:
- develop innovative therapeutic strategies for the treatment of haemophilia.
- understand the role of PN-1 in pathologies associated with a deregulated angiogenesis, such as diabetic nephropathy or peripheral artery disease.
- inestigate how it can regulate inflammatory responses.
In collaboration with the Team 6 neuroplasticity group, we also aim at investigating the role of PN-1 in post-stroke cerebral remodeling.