Selected Publications

The under-appreciated world of the serpin family of serine proteinase inhibitors.
Bouton MC, Geiger M, Sheffield WP, Irving JA, Lomas DA, Song S, Satyanarayanan RS, Zhang L, McFadden G, Lucas AR.
EMBO Mol Med. 2023 Jun 7;15(6):e17144. doi: 10.15252/emmm.202217144.

Novel ELISA for the specific detection of protease NEXIN-1 in human biological samples.
Venisse L, François D, Madjène C, Brouwers E, de Raucourt E, Boulaftali Y, Declerck P, Arocas V, Bouton MC.
Res Pract Thromb Haemost. 2022 Jul 19;6(5):e12756. doi: 10.1002/rth2.12756.

Syndecan-1 Is Overexpressed in Human Thoracic Aneurysm but Is Dispensable for the Disease Progression in a Mouse Model.
Zalghout S, Vo S, Arocas V, Jadoui S, Hamade E, Badran B, Oudar O, Charnaux N, Longrois D, Boulaftali Y, Bouton MC, Richard B.
Front Cardiovasc Med. 2022 Apr 25;9:839743. doi: 10.3389/fcvm.2022.839743.

Protease Nexin-1 in the Cardiovascular System: Wherefore Art Thou?
Madjene C, Boutigny A, Bouton MC, Arocas V, Richard B.
Front Cardiovasc Med. 2021 Mar 31;8:652852. doi: 10.3389/fcvm.2021.652852.

Protease nexin‑1 deficiency increases mouse hindlimb neovascularization following ischemia and acceleratesfemoral artery perfusion.
Selbonne S., Madjene C., Salmon B., Boulaftali Y., Bouton M.C., Arocas V.
Sci Rep 11, 13412 2021. https://doi.org/10.1038/s41598-021-92794-9

Serpins, New Therapeutic Targets for Hemophilia.
Aymonnier K, Kawecki C, Arocas V, Boulaftali Y, Bouton MC
Review – Thromb Haemost, 28 Sep 2020 | PMID: 32987444

Development and characterization of single-domain antibodies neutralizing protease nexin-1 as tools to increase thrombin generation.
Kawecki C, Aymonnier K, Ferrière S, Venisse L, Arocas V, Boulaftali Y, Christophe OD, Lenting PJ, Bouton MC, Denis CV
J Thromb Haemost, 04 Jun 2020 | PMID: 32495984

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia.
Aymonnier K, Kawecki C, Venisse L, Boulaftali Y, Christophe OD, Lenting PJ, Arocas V, de Raucourt E, Denis CV, Bouton MC
Blood, 134(19):1632-1644, 01 Nov 2019 | PMID: 31383642

Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice.
François D, Arocas V, Venisse L, Aymonnier K, Idir L, Martos R, Gazit S, Couty L, Jandrot-Perrus M, Camerer E, Boulaftali Y, Bouton MC
Blood Adv, 2(18):2389-2399, 01 Sep 2018 | PMID: 30254103 | PMCID: PMC6156894

Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta.
Boukais K, Borges LF, Venisse L, Touat Z, François D, Arocas V, Jondeau G, Declerck P, Bouton MC, Michel JB
Cardiovasc Pathol, 32:15-25, 24 Oct 2017 | PMID: 29149696

Uptake of Plasmin-PN-1 Complexes in Early Human Atheroma.
Boukais K, Bayles R, Borges Lde F, Louedec L, Boulaftali Y, Ho-Tin-Noé B, Arocas V, Bouton MC, Michel JB
Front Physiol, 7:273, 30 Jun 2016 | PMID: 27445860 | PMCID: PMC4927630

Protease nexin-1 regulates retinal vascular development.
Selbonne S, Francois D, Raoul W, Boulaftali Y, Sennlaub F, Jandrot-Perrus M, Bouton MC, Arocas V
Cell Mol Life Sci, 72(20):3999-4011, 25 Jun 2015 | PMID: 26109427

Selective neutralization of the serpin protease nexin-1 by a specific monoclonal antibody.
François D, Venisse L, Brouwers E, Arocas V, Declerck P, Bouton MC
Br J Haematol, 172(4):631-633, 26 May 2015 | PMID: 26010932

Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression.
François D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC
Lab Invest, 94(11):1237-1246, 08 Sep 2014 | PMID: 25199049

Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.
Boulaftali Y, François D, Venisse L, Jandrot-Perrus M, Arocas V, Bouton MC
Arterioscler Thromb Vasc Biol, 33(7):1647-1654, 09 May 2013 | PMID: 23661674

In vitro and in vivo antiangiogenic properties of the serpin protease nexin-1.
Selbonne S, Azibani F, Iatmanen S, Boulaftali Y, Richard B, Jandrot-Perrus M, Bouton MC, Arocas V
Mol Cell Biol, 32(8):1496-1505, 13 Feb 2012 | PMID: 22331468 | PMCID: PMC3318585

Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.
Bouton MC, Boulaftali Y, Richard B, Arocas V, Michel JB, Jandrot-Perrus M
Review – Blood, 119(11):2452-2457, 10 Jan 2012 | PMID: 22234688

Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis.
Boulaftali Y, Ho-Tin-Noe B, Pena A, Loyau S, Venisse L, François D, Richard B, Arocas V, Collet JP, Jandrot-Perrus M, Bouton MC
Circulation, 123(12):1326-1334, 14 Mar 2011 | PMID: 21403095 | PMCID: PMC3316939

Anticoagulant and antithrombotic properties of platelet protease nexin-1.
Boulaftali Y, Adam F, Venisse L, Ollivier V, Richard B, Taieb S, Monard D, Favier R, Alessi MC, Bryckaert M, Arocas V, Jandrot-Perrus M, Bouton MC
Blood, 115(1):97-106, 23 Oct 2009 | PMID: 19855083